1250 Mcduff Avenue S, Jacksonville, FL

$599,000

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2

Beds

2

Baths

2,800

Square feet

0.13

Acres

Summary of 1250 Mcduff Avenue S, Jacksonville - MLS# 2129340

1250 Mcduff Avenue S (zip: 32205), MLS# 2129340 is located in the Avondale neighborhood of Jacksonville, FL.

Description of 1250 Mcduff Avenue S, Jacksonville - MLS# 2129340

Owner financing available! Located in the heart of Jacksonville's vibrant Riverside Avondale Historic District, this versatile mixed-use property at 1250 McDuff Avenue South offers a rare opportunity to live, work, or invest in one of the city's most walkable and sought-after neighborhoods. The first-floor commercial space spans approximately 1,800 square feet and allows a wide range of uses by right, including medical or professional office, retail sales, service establishments, and restaurant use--making it ideal for owner-operators or investors seeking flexible income potential. Commercial Neighborhood zoning is scarce in Riverside Avondale, with only three small areas--less than 35 properties total--making this a highly desirable location to operate a business. Upstairs, the residential unit is a charming 2-bedroom, 1 bathroom apartment of roughly 1,100 square feet, featuring hardwood floors and a charming midcentury bathroom that adds character and warmth. The layout is well suited for an owner-occupant, employee housing, or long-term rental. The location creates for a high rental value as it is within walking distance to the Avondale and King Street Shopping Districts, the Riverside Community Garden, Willowbranch Park, and the St. Johns River. The commercial space was leased to long-term tenants at below-market rents, presenting clear upside for future value. Whether you envision a live/work setup, renting one space to offset expenses, or utilizing the full space for one commercial use, the options here are compelling. While located within the historic district, the building itself is not a contributing structure, offering added flexibility for future use. Take advantage of this rare opportunity for a mixed-use property in one of the most desirable neighborhoods in Jacksonville. NOTE: This property is also listed under Residential MLS #2129351 and Commercial MLS #2129351

Features of 1250 Mcduff Avenue S

MLS® # 2129340
Price $599,000
Bedrooms 2
Bathrooms 2.00
Full Baths 2
Square Footage 2,800
Acres 0.13
Year Built 1949
Type Residential Income
Sub-Type Multi Family
Status Active

Community Information : Jacksonville

Address 1250 Mcduff Avenue S
Area 032-Avondale
Subdivision Avondale
City Jacksonville
County Duval
State FL
Zip Code 32205

Amenities of 1250 Mcduff Avenue S

Utilities Cable Available, Electricity Available, Sewer Available, Water Available
Parking Garage, Off Street, On Street
# of Garages 1
Is Waterfront No
Has Pool No

Interior of 1250 Mcduff Avenue S

Appliances Dryer, Electric Range, Electric Water Heater, Refrigerator, Washer
Heating Central
Cooling Central Air
Fireplace No
# of Stories 2

Exterior of 1250 Mcduff Avenue S

Lot Description Historic Area
Roof Shingle
Construction Brick, Wood Siding

Additional Information On 1250 Mcduff Avenue S

Date Listed April 24th, 2026
Days on Market 138
RE / Bank Owned No
Age Restriction No
New Construction No

Listing Details of 1250 Mcduff Avenue S

OfficeCOWFORD REALTY & DESIGN LLC

Listing Map of 1250 Mcduff Avenue S

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1250 Mcduff Avenue S Jacksonville FL 32205 - MLS# 2129340

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